Monash University is conducting a study to understand the causes of gastrointestinal symptoms in women with endometriosis.
Endometriosis affects around 1 in 10 Australian women and many of these women also suffer from IBS and/or gastrointestinal symptoms (e.g. bloating, abdominal pain, constipation and diarrhoea). Currently, we do not know what causes the gastrointestinal symptoms associated with endometriosis.
This pilot study is trying to work out the cause of gastrointestinal symptoms in women with endometriosis. Specifically, whether they are caused by chronic inflammation and/or from having a highly sensitive gut wall.
We are looking for Melbourne-based women aged between 18 and menopause who have been diagnosed with endometriosis AND irritable bowel syndrome.
People living outside of Melbourne (unless you can travel to Melbourne for the rectal barostat appointment)
Pregnant or breastfeeding women
Women suffering from another gut disorder such as coeliac disease
Women recovering from recent abdominal surgery
Women with a history of hysterectomy, oophorectomy or bowel resection
Completing a screening appointment via Zoom with our study gastroenterologist
Completing a one-off questionnaire that asks questions about gastrointestinal symptoms, endometriosis, quality of life and mental health. This can be completed at home.
Collecting 1 stool and 1 vaginal sample at home.
Undergoing a rectal barostat procedure at the Alfred Hospital (outpatients clinic)
A rectal barostat procedure is used to test how well you feel things in the rectum. The procedure is completed by a gastroenterologist and involves:
Attending an appointment at the Alfred Hospital following an overnight fast
Completing a urine pregnancy test (must be negative to proceed)
Answering some questions about your gastrointestinal symptoms and bowel habits.
Having a water enema to clean out the lower part of your bowel into the toilet
Undergoing a brief rectal examination
Having a thin tube (with a bag attached) eased gently into your rectum. Air will then be inflated into the bag and you will register the sensations you feel
Having 4 rectal biopsies taken.
You may experience some discomfort during the rectal barostat procedure and may feel like you need to have a bowel movement. However, if at any time you feel an intolerable sensation, you can press a button and the procedure will be terminated.
Around 3.5 hours in total
Completing the survey and collecting the samples at home may take ~ 1 hour.
The screening appointment via Zoom will take ~30 minutes
The rectal barostat procedure will take approximately 2 hours.
To take our screening survey, click here
To download the participant information and consent form, click here
To find out more or express your interest, please email Dr Jane Varney - email@example.com